Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis a real-world dataset positive severe acute respiratory syndrome 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that was substantially reduced for infections occurring 12–37 d first dose vaccine. These loads hint at potentially lower infectiousness, contributing to vaccine effect on virus spread. Breakthrough SARS-CoV-2 12 or more days mRNA were associated than those unvaccinated individuals, suggesting infectiousness.